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KMID : 1143820210170020084
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Anxiety and Mood
2021 Volume.17 No. 2 p.84 ~ p.91
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Comparison of Mismatch Negativity According to Suicidal Ideation in Patients With Major Depressive Disorder
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Lee Min-Ji
Lee Yeon-Jung
Hwang Jae-Uk
Woo Sung-Il
Kim Min-Jae
Kang Byung-Joo
Kim Young-Geun
Hahn Sang-Woo
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Abstract
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Objective : Mismatch negativity (MMN) is known to reflect several abnormalities of cognitive functioning.
This study is aimed to investigate the differences in MMN among major depressive disorder (MDD) patients with or without suicidal ideation.
Methods : Sixty-seven patients with MDD were recruited into this study. MMN was measured by a 64-channel electroencephalography (EEG) using oddball paradigm over the front-central area. Clinical characteristics were assessed using the Beck Anxiety Inventory (BAI), the Beck Depression Inventory-II (BDIII), and the Beck Scale for Suicide ideation (SSI-BECK). Patients were divided into two groups, no suicidal ideation (N=12) and suicidal ideation (N=55), depending on the presence of suicide ideation in SSI-BECK questionnaires.
Results : The MMN latencies were significantly longer in the MDD patients with suicidal ideation than in the MDD patents without suicidal ideation (p<0.05). The MMN amplitudes were not significantly different between the two groups.
Conclusion : Suicidal ideation may be associated with longer MMN latencies, and it suggests that MMN may play a potential role in assessing the suicidal risk among MDD patients.
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KEYWORD
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Mismatch negativity, Suicidal ideation, Major depressive disorder
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